Groundbreaking support for modern skin: The origins, science and results behind True Skin Alchemy

True Skin Alchemy: The origins, science and clinical results behind our skin support supplement

Skin health is a life companion. But skin was never designed to be just aesthetics.  At Ancient + Brave, we recognise that while skin creams create beautiful results on the surface, true skin barrier resilience begins below the surface.

That’s why, as wellbeing experts, rather than ask what skin needs to be smoothed, plumped or corrected, we ask, “What does skin need from within?  That question led us to create True Skin Alchemy, our new evidence-based, ingestible skin supplement designed to hydrate, protect, and defend the skin.
Discover the clinically-backed ingredients behind the formula as Dr Jenna Macciochi explains the science we used to bring this barrier-reinforcing ritual into being.

At a glance: 

+ Modern skincare, while essential, somewhat reduces skin care to aesthetics. Ingestible takes a different approach, giving your skin the support it needs from within.

+ Your skin shields you from daily stresses like UV radiation, pollution, and microbes. But that can leave the barrier feeling dry, dull and less radiant than it once was.

+ Periods of hormonal transition can also compromise skin by influencing collagen production, ceramide content, hydration and skin thickness.

+ Ingestible skincare like True Skin Alchemy provides the nutrients, lipids, and bioactive compounds your skin barrier needs to perform at its best

+ True Skin Alchemy has been created for women at every stage of life to support brighter, stronger, and better-hydrated skin from within

Beyond skin creams: The need for inside-out skin health

For many women, there comes a time when skin starts to need more. Products that used to work feel less effective. The glow that came easily now needs more effort to maintain. 

Modern skincare conversations often reduce this shift in skin health to appearance - wrinkles to erase, dryness to fix, and glow to optimise - when really, the better question is not ‘what does skin need to look better’ but ‘what does skin need to function’.

You see, skin is so much more than a static overcoat. It's a complex, multi-layered microbial ecosystem that exists in layers: the epidermis at the surface, the deeper dermis beneath it, and the supporting structures below.  It helps regulate temperature and fluid balance. Hosts a complex microbial ecosystem. Produces antimicrobial peptides. Detects light. Responds to stress hormones. And its ability to function is shaped by both the inside out and the outside in.

Outside in: UV radiation, pollution, microbes, stress and environmental change (Vierkötter et al., 2010; Krutmann et al., 2014; Coats et al., 2021).

Inside out: Hormones, sleep, nutrition, inflammation, hydration and nervous system balance (Chen and Lyga, 2014; Oyetakin-White et al., 2015; Thornton, 2013).

Over time, these daily stresses that skin shields us against show up on the surface as dryness, dullness and a loss of radiance.  While the reasons for this are many, the biology usually points to a compromised barrier and a shift in the balance between repair and damage, often referred to as inflammageing (Furman et al., 2019). 

When this happens, hydration becomes harder to maintain, diminishing the skin’s capacity to protect and defend against oxidative and environmental stress (Rinnerthaler et al., 2015). This is particularly true during menopause, where declining oestrogen can compromise the barrier by influencing collagen production, ceramide content, hydration, wound healing, and skin thickness (Thornton, 2013).

Topical skin care, like moisturisers, helps address the surface layer of each of these problems, but the skin barrier is not a surface; it is a tissue reliant on nutrients, lipids, and bioactive compounds delivered via the bloodstream. That’s where  True Skin Alchemy comes in.

True Skin Alchemy: Protecting skin from within

True Skin Alchemy is an intelligent skin ingestible created using the understanding that resilient, hydrated, visibly healthy skin is built from within, not just maintained from the outside. 

Bringing together seven clinically supported ingredients, including three patented, bioavailability-optimised forms: HAPLEX®Plus hyaluronic acid, Ceramosides™, and Mesoporosil® silica) This daily ritual delivers the building blocks skin needs to build a strong, effective barrier:

+ Systemic hydration: via hyaluronic acid and ceramides (Kawada et al., 2017; Bizot et al., 2017; Kern et al., 2024).

+ Lipid barrier support: via plant ceramides, which mirror the ceramide species that make up around half of the skin’s lipid matrix (Coderch et al., 2003; Bizot et al., 2017; Kern et al., 2024).

+ Photoprotective and environmental defence: via Polypodium leucotomos extract (Palma, Vidal and Gonzales, 2014; Rodriguez-Lomba et al., 2015; Parrado et al., 2016; Villa et al., 2017).

+ Antioxidant support: via grape seed extract polyphenols and vitamin C (Bagchi et al., 2003; Katiyar, 2020; Sochorova et al., 2020; European Commission, 2012).

+ Connective tissue support: via bioavailable silicium (Barel et al., 2005; Jugdaohsingh, 2007; Coste-Manière et al., 2022; Mohta et al., 2025; Mannu et al., 2026).

Suitable for all skin types and created for women at every stage of life,  this intelligent skin support supplement is particularly helpful for skin that feels stressed, depleted, hormonally influenced or environmentally challenged.  With consistent use, it supports your topical skin care, promoting a brighter, more radiant complexion alongside a stronger, more resilient skin barrier.

Inside the formula: how each active earns its place

Each True Skin Alchemy active was selected for a specific evidence-backed role:

HAPLEX®Plus Low molecular weight hyaluronic acid:  Hyaluronic acid is a skin care staple thanks to its ability to create temporary surface hydration. When taken orally, it acts deeper, delivering skin-plumping hydration, bounce, and elasticity to where lines and wrinkles begin.

“We selected HAPLEX®Plus because its low molecular weight was specifically designed for enhanced absorption and bioavailability.  Clinical studies have demonstrated measurable improvements in wrinkle depth, skin suppleness, firmness, and elasticity over 12 weeks (Oe et al., 2014; Kawada et al., 2017).  Dr. Jenna Macciochi

Ceramosides™ Plant-derived ceramides: Ceramides make up around half of the skin’s lipid matrix by weight (Coderch et al., 2003), and ceramide content has been observed to decline with age and seasonal stress (Rogers et al., 1996). Ceramosides™ is a patented plant-derived ceramide complex clinically studied for improvements in skin hydration, smoothness and barrier function within weeks of supplementation (Bizot et al., 2017; Kern et al., 2024).

Mesoporosil®  Bioavailable silica: Silica is rarely discussed in skincare conversations, yet it plays an important role in supporting firmness, elasticity, hydration, radiance, and skin structure ((Jugdaohsingh, 2007). Oral supplementation with bioavailable forms of silicon has been associated with improvements in skin firmness, elasticity and roughness in women with photodamaged skin (Barel et al., 2005). Mesoporosil® uses patented mesoporous technology to deliver silicium in a more bioavailable form, and has been studied for improvements in firmness, hydration, elasticity and wrinkle appearance (Coste-Manière et al., 2022; Mohta et al., 2025; Mannu et al., 2026).

Polypodium leucotomos, an ancient fern extract: This tropical fern has evolved complex antioxidant defence systems in response to intense UV exposure. While it is not a replacement for sunscreen, oral Polypodium leucotomos extract has been studied for its ability to modulate markers of UV-induced oxidative stress, inflammation, and matrix metalloproteinase activity, supporting skin’s response to environmental challenge (Palma, Vidal and Gonzales, 2014; Rodriguez-Lomba et al., 2015; Parrado et al., 2016; Villa et al., 2017).

Grape seed extract: Standardised to 95% polyphenols, this antioxidant-rich active provides the environmental defence layer. Its power lies in its antioxidant properties, which help to counteract collagen degradation, inflammation, and barrier disruption caused by daily oxidative stress from sunlight, stress, and the environment (Bagchi et al., 2003; Fisher et al., 1997; Rinnerthaler et al., 2015; Katiyar, 2020; Sochorova et al., 2020; Pittayapruek et al., 2016).

Vitamin C as magnesium ascorbate: In a formulation built around barrier resilience, collagen support and antioxidant activity are crucial. Vitamin C in its magnesium ascorbate form contributes to normal collagen formation and provides additional antioxidant protection against oxidative stress (EFSA-authorised health claims, European Commission, 2012).. 

Biotin Vitamin B7: Biotin contributes to the maintenance of normal skin and to normal macronutrient metabolism, supporting the metabolic environment in which the formula’s other actives operate  (EFSA-authorised health claims, European Commission, 2012)..

Inner Circle Insights

Formulating with clinical-grade ingredients is one thing. Understanding how a supplement performs in real women, across real skin concerns and real daily life, is another. That's why we built the Inner Circle - our customers' voices in our product development process.

55 customers aged 35-55 with no history of sunbed use tested True Skin Alchemy by making it part of their daily skin ritual. 

After 8 weeks:

+ Perceived dryness fell by nearly 40%

+ Skin barrier strength rose from 3.0 to 4.0 out of 5

+ Skin feels strong and resilient, rose from 2.7 to 3.9 out of 5

+ Overall skin health rating climbed from 3.2 to 4.1 out of 5

+ Skin satisfaction rose from 2.7 to 4.0 out of 5

+ Skin looks healthy overall, rose from 3.1 to 4.0 out of 5

While 40% of our Inner Circle testers considered their skin to be dry, the majority (66%) identified ageing skin as their main concern. Many already use collagen daily. Many considered themselves difficult to impress. And yet the feedback that came back was deeply compelling* with 78% saying it would change nothing about the product.

One of the things I found most interesting was that many women described not only visible changes, but a feeling of resilience.

*"The inside of my skin on my face felt more alive, more nourished, thicker and healthier. It felt nicer to be inside my skin."* —  Inner Circle participant.

*"I have had a couple of comments over the last week from colleagues who have asked if I have had 'treatment' or am using something different on my face. I haven't."* —  Inner Circle participant.

*"I love it. I catch my reflection and think wow."* — Inner Circle participant.

Clinical-grade evidence, for a clinical-grade formula

Beyond our Inner Circle citizen science sturdy, True Skin Alchemy is currently undergoing an independent, IRB-approved, double-blind, randomised, placebo-controlled clinical trial in women over 40 with dry and ageing skin — the exact cohort this formulation was designed for.

The study measures hydration, barrier integrity, elasticity, firmness, wrinkle appearance, and clinical assessments of overall skin quality using validated dermatological tools, including Corneometer®, Tewameter®, Cutometer®, and profilometry analysis.

We commissioned this trial because we believe evidence should exist on the complete formula itself, not just the individual ingredients in isolation.

While the results are not ready yet, we are telling you this because the decision to run a pharmaceutical-grade trial on a beauty supplement shows how seriously we take the evidence, and how seriously we take you. 

The trial results are expected in June 2026, and, regardless of the results, we will publish them here because that is what scientific integrity looks like. 

Where does True Skin Alchemy fit into your skin care routine? 

Now that you know what True Skin Alchemy is and why we created it, find out how it can work for you.

We believe that a well-nourished barrier is more receptive to everything you put on top of it, and designed True Skin Alchemy to complement your existing skin care routine.

In addition to supporting your skin creams to work harder, True Skin Alchemy also pairs perfectly with your True or Wild collagen ritual.  The simplest way to understand this is to think of collagen as building the architecture, while True Skin Alchemy defends it.  

Collagen supplements work at the level of dermal structure — stimulating fibroblast activity, supporting collagen density, and reducing visible signs of structural ageing. 

True Skin Alchemy works at the level of the barrier environment that surrounds and protects that structure: sealing the lipid matrix, reinforcing hydration, providing antioxidant and photoprotective defence against the daily stressors that degrade everything collagen is working to build.

Taking both together offers complete inside care. Several Inner Circle participants noted that their topical products performed better once they started True Skin Alchemy — moisturisers absorbed more evenly, and foundations sat differently. 

That said, True Skin Alchemy also performs well on its own, and can be paired with True Omegas and True Glow by those who simply want targeted barrier and hydration support without the structural focus.

Closing thoughts: 

Skin was never designed to be just aesthetics, and it deserves more than surface care.

The evidence base for oral skin health supplementation has matured considerably in the last decade. We know more now about how ceramides are absorbed and where they go.  We know more about the photoprotective mechanisms of polyphenol-rich botanicals. We have better technology for creating bioavailable forms of minerals like silica that previously couldn't be delivered effectively. 

We are at a point where a genuinely well-designed ingestible skincare product can do things that would not have been possible — or provable — ten years ago. True Skin Alchemy brings that together. Seven ingredients. A clear mechanism for each. Independent clinical evidence at the ingredient level.  The science is there. The formula is ready. Inside-out skincare has arrived. True Skin Alchemy is where it begins.

References

Harvard format. References combine those supplied in the True Skin Alchemy — Ingredients + Science deck with additional peer-reviewed references sourced to substantiate previously flagged claims.

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Barel, A., Calomme, M., Timchenko, A., De Paepe, K., Demeester, N., Rogiers, V., Clarys, P. and Vanden Berghe, D. (2005) ‘Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin’, Archives of Dermatological Research, 297(4), pp. 147–153. Available at: https://doi.org/10.1007/s00403-005-0584-6 (Accessed: 21 May 2026).

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Mannu, N., Bourjac, T., Van Gijseghem, G., Monsuur, F., Rabasso, N. and Coste-Manière, I. (2026) ‘From dissolution to dermal benefits: in vitro, ex vivo, and in vivo evaluation of Mesoporosil® as a highly bioavailable silicium source’, CosmoDerma, 6, p. 33. Available at: https://doi.org/10.25259/CSDM_210_2025 (Accessed: 1 April 2026).

Mohta, A., Mannu, N., Monsuur, F.H. and Morello, G.A. (2025) ‘Efficacy and safety of mesoporosil treatment in enhancing skin firmness, hydration, and elasticity: an 84-day clinical trial’, CosmoDerma, 5, p. 33. Available at: https://cosmoderma.org/efficacy-and-safety-of-mesoporosil-treatment-in-enhancing-skin-firmness-hydration-and-elasticity-an-84-day-clinical-trial/ (Accessed: 1 April 2026).

Oe, M., Mitsugi, K., Odanaka, W., Yoshida, H., Matsuoka, R., Seino, S., Kanemitsu, T. and Masuda, Y. (2014) ‘Dietary hyaluronic acid migrates into the skin of rats’, The Scientific World Journal, 2014, 378024. Available at: https://doi.org/10.1155/2014/378024 (Accessed: 21 May 2026).

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Palma, S., Vidal, A. and Gonzales, S. (2014) ‘Sun protection in a pill: the photoprotective properties of Polypodium leucotomos extract’, International Journal of Dermatology, 53(10), pp. 1208–1211. Available at: https://onlinelibrary.wiley.com/doi/10.1111/ijd.12611 (Accessed: 1 April 2026).

Parrado, C., Mascaraque, M., Gilaberte, Y., Juarranz, A. and Gonzalez, S. (2016) ‘Fernblock (Polypodium leucotomos extract): molecular mechanisms and pleiotropic effects in light-related skin conditions, photoaging and skin cancers, a review’, International Journal of Molecular Sciences, 17(7), p. 1026. Available at: https://doi.org/10.3390/ijms17071026 (Accessed: 21 May 2026).

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FAQs 

Who is True Skin Alchemy for? Is it suitable for all skin types?

True Skin Alchemy is an advanced inside-out skin defence capsule designed to reinforce hydration and strengthen skin barrier function. Formulated with targeted ingredients proven to nourish skin at the source, it is suitable for all skin types but may be particularly beneficial for women of menopausal age navigating declining oestrogen levels.

What makes True Skin Alchemy unique?

Formulated through the lens of inside-out skin health, the formula brings together seven clinically supported ingredients, including three patented, bioavailability-optimised forms: HAPLEX®Plus hyaluronic acid, Ceramosides™ plant ceramides, and Mesoporosil® silica. Each was selected for a specific evidence-backed role in supporting hydration, lipid barrier integrity, connective tissue structure, antioxidant defence, and resilience against environmental stressors.

Unlike most beauty supplements, True Skin Alchemy is currently undergoing an independent, double-blind, randomised, placebo-controlled clinical trial in women over 40 because we believe evidence should exist on the finished formula, not just the ingredients within it.

Does True Skin Alchemy replace my topical skincare routine?

Not at all, instead it introduces a new daily skincare ritual, sitting naturally alongside topical solutions as part of a more complete approach to skin. Developed using clinically backed and recognised skincare ingredients such as hyaluronic acid and ceramides,  it addresses a clear need: skin looks and functions at its best when it can retain moisture,  resist modern environmental stress, and remain visibly nourished.

Is True Skin Alchemy a replacement for sunscreen?

True Skin Alchemy is not an SPF product and works very differently from sunscreen. An ingestible skin defence product, its UV defence mechanism comes from Polypodium leucotomos, a tropical fern extract, which has been clinically studied for its ability to help support skin exposed to UV-induced oxidative stress, working synergistically with sunscreen, not replacing it.

How does True Skin Alchemy work alongside collagen?

True Skin Alchemy complements collagen beautifully: while collagen helps to reduce the signs of visible skin ageing by supporting the structure of your skin, True Skin Alchemy feeds the barrier the raw materials it needs to hydrate and defend itself. It complements collagen by doing what collagen doesn't: protecting and sealing the barrier environment that keeps skin structurally strong.

Why take a skin supplement rather than just using better topical products?

When our skin starts to struggle, when it feels persistently dry, reactive, dull, and less resilient than it used to be, the underlying biology usually points to three interconnected issues. The lipid barrier has become compromised. Systemic hydration is insufficient. And the skin's capacity to protect and defend against oxidative and environmental stress has diminished.

Topical products can address the surface layer of each of these problems; no amount of hyaluronic acid serum, however well formulated, can replicate what happens when your body receives the raw materials it needs to build barrier integrity from the inside out.

Is True Skin Alchemy clinically proven to work?

Unlike most beauty supplements, True Skin Alchemy is currently undergoing an independent, double-blind, randomised, placebo-controlled clinical trial to pharmaceutical standards, results due June 2026, because we believe the evidence should be tested on the formula as a whole, in the real women it was designed for.

*True Skin Alchemy Inner Circle Study, conducted with 55 women aged 35-55 in April 2026.